1333079-97-2Relevant academic research and scientific papers
Direct arylation of imidazo[2,1-b]thiazoles and thiazoles with aryl iodides via CuCl2/PPh3-catalyzed C-H bond functionalization
Ma, Yuchang,Na, Min,Gu, Yanfang,Huang, Guoli,Li, Xia,Chen, Yegao
, p. 165 - 169 (2015/03/30)
With PPh3 acting as a ligand, a convenient method for CuCl2-catalyzed arylation of imidazo[1,2-b]thiazoles and thiazoles with aryl iodides under mild reaction conditions is described. Preliminary mechanistic studies of this arylation involving a formal Cu(I) to Cu(0) and Cu(II) route by convergent disproportionation of the copper mediator are also reported.
Ligand-free copper-catalyzed regioselective C-2 arylation of imidazo[2,1-b]thiazoles
Huang, Guoli,Sun, Hongsheng,Qiu, Xiaojie,Jin, Can,Lin, Chen,Shen, Yingzhong,Jiang, Juli,Wang, Leyong
supporting information; experimental part, p. 5224 - 5227 (2011/12/04)
An effective, regioselective C-2 arylation of imidazo[2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary mechanistic studies of this arylation are also reported.
