1333084-19-7

Basic information

• Product Name: (4S,5R)-N-[(1S,2R)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one
• CAS NO: 1333084-19-7
• Molecular Weight: 374.437
• Mol File: 1333084-19-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S,5R)-N-[(1S,2R)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-N-[(1S,2R)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one(1333084-19-7)
• EPA Substance Registry System: (4S,5R)-N-[(1S,2R)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one(1333084-19-7)

Safety Data

• Hazardous Substances Data: 1333084-19-7(Hazardous Substances Data)

Upstream product

• 402848-96-8 tert-butyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16251-45-9 (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one 
• 951173-22-1 (+/-)-cis-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid 

Downstream Products

• 951173-22-1 (+)-(1S,2R)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid 
• 951173-22-1 (+)-(1R,2R)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid 

Relevant articles and documents

A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids

The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-one allows easy diastereoisomeric separation and presents the advantage of allowing the non-destructive cleavage of the chiral auxiliary either by hydrolysis or by ammonolysis, thus providing an efficacious access to N-protected derivatives of all four stereoisomers of Boc-2-aminocyclobutanecarboxylic acid.