13331-76-5Relevant academic research and scientific papers
A biomimetic approach to lanthionines
Aydillo, Carlos,Avenoza, Alberto,Busto, Jesus H.,Jimenez-Oses, Gonzalo,Peregrina, Jesus M.,Zurbano, Maria M.
supporting information; experimental part, p. 334 - 337 (2012/03/26)
The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin.
ALPHA-HELICAL MIMETICS
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Page/Page column 189; 194, (2010/02/15)
Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralising pro-survival Bcl-2 proteins. Use of the benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
