1333141-08-4

Upstream product

• 501433-14-3 methyl 2,6-difluoro-3-iodobenzoate 
• 385-00-2 2,6-difluorobenzoic acid 
• 229178-74-9 2,6-difluoro-3-iodobenzoic acid 
• 1333141-18-6 methyl 6-(3-chloro-2-fluorobenzyl)-5-fluoro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1333141-28-8 C₂₁H₁₇ClF₃NO₃ 
• 1333140-90-1 methyl 2-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoyl)-3-(dimethylamino)acrylate 
• 1333140-89-8 methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate 
• 1333140-88-7 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoic acid 
• 1333140-87-6 methyl 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoate 

Downstream Products

• 1333140-98-9 6-(3-chloro-2-fluorobenzyl)-1-cyclopropyl-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors

A series of new quinolone-3-carboxylic acids as HIV-1 integrase inhibitors featuring a fluorine atom at C-5 position were synthesized and evaluated for their antiviral activity in C8166 cell culture. These newly synthesized compounds showed anti-HIV activ

Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity

A series of new quinolone-3-carboxylic acids featuring a hydroxyl group at C-5 position were synthesized and evaluated for their in vitro activity against HIV in C8166 cell culture. All the compounds showed anti-HIV-1 activity with low micromolar to submi