NHS-PEG4-(m-PEG4)3-ester is a polyethylene glycol (PEG) derivative that is commonly utilized in the fields of bioconjugation and protein labeling. NHS-PEG4-(m-PEG4)3-ester features a succinimidyl ester group attached to a PEG chain with three repeating monodisperse PEG units. It is specifically designed to covalently and efficiently bind to primary amines present on proteins, peptides, or other molecules, resulting in the formation of stable and biocompatible conjugates. The PEGylation process facilitated by NHS-PEG4-(m-PEG4)3-ester enhances the solubility, stability, and circulation time of biomolecules in the body, which is instrumental in the development of pharmaceutical and biotechnological products.
1333154-70-3
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Basic information
- Product Name: NHS-PEG4-(m-PEG4)3-ester
- Synonyms: NHS-PEG4-(m-PEG4)3-ester
- CAS NO:1333154-70-3
- Molecular Formula: C60H110N6O28
- Molecular Weight: 1363.5388
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1333154-70-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.22±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.65±0.46(Predicted)
- CAS DataBase Reference: NHS-PEG4-(m-PEG4)3-ester(CAS DataBase Reference)
- NIST Chemistry Reference: NHS-PEG4-(m-PEG4)3-ester(1333154-70-3)
- EPA Substance Registry System: NHS-PEG4-(m-PEG4)3-ester(1333154-70-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1333154-70-3(Hazardous Substances Data)
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1333154-70-3 Usage
Uses
Used in Bioconjugation Applications:NHS-PEG4-(m-PEG4)3-ester is used as a bioconjugation agent for the purpose of attaching proteins, peptides, or other molecules to create stable conjugates. The PEGylation process increases the solubility and stability of these biomolecules, which is crucial for their effective use in various applications.
Used in Protein Labeling:
In protein labeling, NHS-PEG4-(m-PEG4)3-ester serves as a labeling agent to modify proteins with PEG chains. This modification can improve the protein's properties, such as enhancing its resistance to proteolytic degradation and prolonging its circulation time in the body, which is beneficial for in vivo imaging and therapeutic applications.
Used in Pharmaceutical Development:
NHS-PEG4-(m-PEG4)3-ester is used as a pharmaceutical development tool for the PEGylation of therapeutic proteins and peptides. The increased stability and circulation time provided by PEGylation can lead to improved pharmacokinetics and therapeutic efficacy of the drug candidates.
Used in Biotechnological Product Development:
In the biotechnological industry, NHS-PEG4-(m-PEG4)3-ester is utilized for the development of biotech products, such as enzymes and other biocatalysts, where PEGylation can enhance their performance in industrial applications by improving their stability and reusability.
Used in Drug Delivery Systems:
NHS-PEG4-(m-PEG4)3-ester is employed in the design of drug delivery systems to improve the bioavailability and targeting of therapeutic agents. The PEGylation of drug carriers can reduce their immunogenicity and increase their half-life in the bloodstream, allowing for more effective drug delivery to the target site.
Check Digit Verification of cas no
The CAS Registry Mumber 1333154-70-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,3,1,5 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.Calculate Digit Verification of CAS Registry Number 1333154-70:
(9*1)+(8*3)+(7*3)+(6*3)+(5*1)+(4*5)+(3*4)+(2*7)+(1*0)=123
123 % 10 = 3
So 1333154-70-3 is a valid CAS Registry Number.
1333154-70-3Upstream product
1333154-70-3Downstream Products
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NHS-PEG4-(m-PEG4)3-ester
