1333159-63-9Relevant academic research and scientific papers
Iron-catalyzed cross-coupling of aryltrimethylammonium triflates and alkyl Grignard reagents
Guo, Wang-Jun,Wang, Zhong-Xia
, p. 9580 - 9585 (2013/10/22)
Fe(acac)3 effectively catalyzes reaction of aryltrimethylammonium triflates with β-hydrogen-containing primary or secondary alkyl Grignard reagents in a mixed solvent of THF and NMP at room temperature. A series of functional groups are tolerated under the reaction conditions.
Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation
Xu, Jun,Fu, Yao,Luo, Dong-Fen,Jiang, Yuan-Ye,Xiao, Bin,Liu, Zhao-Jing,Gong, Tian-Jun,Liu, Lei
, p. 15300 - 15303 (2011/11/11)
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.
