13332-74-6

Upstream product

• 78-95-5 chloroacetone 
• 123-31-9 hydroquinone 
• 621-87-4 3-phenoxy-2-propanone 

Downstream Products

• 135897-58-4 4-[(2-methyl-1,3-dioxolan-2-yl)methoxy]phenol 
• 106064-02-2 (Z)-3-[4-(3-tert-Butylamino-2-hydroxy-propoxy)-phenoxy]-4-phenyl-but-3-en-2-one 
• 106063-69-8 (Z)-3-<4-<2-(diethylamino)ethoxy>phenoxy>-4-phenyl-3-buten-2-one 
• 106064-01-1 (Z)-3-[4-(2-Dimethylamino-propoxy)-phenoxy]-4-phenyl-but-3-en-2-one 
• 106063-65-4 (Z)-3-(4-methoxyphenoxy)-4-phenyl-3-buten-2-one 
• 106063-66-5 (E)-3-(4-methoxyphenoxy)-4-phenyl-3-buten-2-one 
• 106064-16-8 (Z)-3-[4-(2-Dimethylamino-1-methyl-ethoxy)-phenoxy]-4-phenyl-but-3-en-2-one 
• 106063-62-1 (Z)-3-<4-(2,3-epoxypropoxy)phenoxy>-4-phenyl-3-buten-2-one 
• 106063-58-5 (Z)-3-(4-hydroxyphenoxy)-4-phenyl-3-buten-2-one 
• 106063-59-6 3-(4-acetoxyphenoxy)-4-phenyl-3-buten-2-one 

Relevant academic research and scientific papers

Synthetic method 4 - alkoxyphenol compounds

The invention discloses a synthetic method of 4 - alkoxyphenol compounds, and belongs to the field of organic chemical synthesis. The method is as follows: An aryl alkyl ether compound is added to the sealing tube. The catalyst dimerization acetic acid rhodium and the oxidizing agent iodobenzene diethyl ester are added, a solvent trifluoroacetic anhydride is added, and the 4 -alkoxyphenol compound is prepared by heating reaction. To the invention, high regioselectivity direct hydroxylation of the aryl alkyl ether compound is realized, the application range of the substrate is wide, the yield is high, the activity after amplification reaction does not significantly decay, and higher yield is still obtained. The utility model has good practicability and industrial application prospect.

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Phenoxypropanolamine compounds

Compounds of the formula (I): STR1 wherein R1 is hydrogen or fluoro and R2 is hydrogen or C1-6 alkyl and salts thereof are described as agents for the treatment of obesity and related conditions. Processes for their preparation and intermediates are described.