1333222-12-0

Basic information

• Product Name: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine
• Synonyms: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine;6-(Difluoromethoxy)pyridin-3-ylboronic acid pinacol ester
• CAS NO: 1333222-12-0
• Molecular Formula: C₁₂H₁₆BF₂NO₃
• Molecular Weight: 271
• Mol File: 1333222-12-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine(1333222-12-0)
• EPA Substance Registry System: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine(1333222-12-0)

Safety Data

• Hazardous Substances Data: 1333222-12-0(Hazardous Substances Data)

Usage

General Description

2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a chemical compound with a complex structure consisting of a pyridine ring attached to a boron-containing group. The difluoromethoxy and tetramethyl substituents further modify the chemical properties and reactivity of the compound. 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine likely has applications in the field of organic synthesis and materials science due to the presence of boron, which is known for its ability to form stable covalent bonds with various organic groups. The difluoromethoxy group also adds electron-withdrawing properties to the molecule, potentially affecting its reactivity and interactions with other chemicals. Overall, this compound represents an important building block for the synthesis of more complex organic molecules and materials.

Upstream product

• 1054483-78-1 2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1895-39-2 sodium chlorodifluoroacetate 
• 269409-70-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 899452-26-7 5-bromo-2-(difluoromethoxy)pyridine 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 13466-38-1 5-bromopyridin-2-ol 

Relevant articles and documents

Use of Inhibitors of the Activity or Function of PI3K

The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.

SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl; a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O; wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.

QUINAZOLINE DERIVATIVES AS PI3K MODULATORS

The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X1, X2, X3, X4 and R5 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.