1333239-48-7Relevant articles and documents
Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis
Dandapani, Sivaraman,Lowe, Jason T.,Comer, Eamon,Marcaurelle, Lisa A.
, p. 8042 - 8048 (2011)
An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macro-lactams were obtained.