1333247-74-7Relevant academic research and scientific papers
A novel entry to spirofurooxindoles involving tandem dearomatization of furan ring and intramolecular friedel- Crafts reaction
Yin, Biao-Lin,Lai, Jin-Qiang,Zhang, Ze-Ren,Jiang, Huan-Feng
, p. 1961 - 1965 (2011/10/09)
A copper sulfate pentahydrate-catalyzed intramolecular Friedel-Crafts reaction using an oxocarbenium species derived from a furan ring as the alkylating agent was developed for the first time. By using this protocol, spirofurooxindoles 9 with multi-reactive sites were synthesized simply and concisely. In addition, selective hydrogenation of the endo-cyclic double bond and full hydrogenation of the endo and exo-cyclic double bonds of spirofurooxindoles 9 provided spirofurooxindoles 11 and 12, respectively. Copyright
