1333313-99-7Relevant articles and documents
Diterpenoid alkaloid lappaconine derivative catalyzed asymmetric α-hydroxylation of β-dicarbonyl compounds with hydrogen peroxide
Li, Zhi,Lian, Mingming,Yang, Fan,Meng, Qingwei,Gao, Zhanxian
, p. 3491 - 3495 (2014)
A new framework derived from the commercially available diterpenoid alkaloid lappaconitine was evaluated as a Bronsted base catalyst for the enantioselective α-hydroxylation of β-dicarbonyl compounds by using 30% hydrogen peroxide as a green and highly practical source of oxygen. This protocol allows convenient access to the corresponding α-hydroxy-β- oxo esters, α-hydroxy-β-oxo amides and (-)-kjellmanianone with up to 98% yield and 92% ee. Copyright