1333317-77-3Relevant academic research and scientific papers
Light click probe for intracellular fluorescence response labeled DNA, and preparation method and application thereof
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Paragraph 0079; 0084, (2017/08/29)
The invention discloses a light click probe for intracellular fluorescence response labeled DNA, and a preparation method and an application thereof. The DNA light click probe with fluorescence response is at least one of tetrazolylcoumarin compounds W1 and W2; and the structural formula of the W1 is represented by formula I, and the structural formula of the W2 is represented by formula II. The probe has nucleus targeting property, a reaction group has a small volume and does not interfere the nucleic acid metabolism process, and the probe has the advantages of fluorescence response, real-time controllable photoinduction, fast reaction speed, high specificity, few byproducts, simple and mild reaction conditions, and easiness in operation; and the DNA light click probe with fluorescence response can be applied to the field of living cell nucleic acid labeling.
Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via scaffold hopping
Yu, Zhipeng,Ho, Lok Yin,Wang, Zhiyong,Lin, Qing
supporting information; scheme or table, p. 5033 - 5036 (2011/10/09)
We report the discovery of two long-wavelength (365 nm) photoactivatable diaryltetrazoles through screening a small library of diaryltetrazoles that were designed using a 'scaffold hopping' strategy. A naphthalene-derived tetrazole showed excellent reacti
