1333374-95-0Relevant academic research and scientific papers
Synthesis, characterization and anti-Trypanosoma cruzi evaluation of ferrocenyl and cyrhetrenyl imines derived from 5-nitrofurane
Arancibia, Rodrigo,Klahn, A. Hugo,Buono-Core, Gonzalo E.,Gutierrez-Puebla, Enrique,Monge, Angeles,Medina, Manuela E.,Olea-Azar, Claudio,Maya, Juan D.,Godoy, Fernando
, p. 3238 - 3244 (2011)
A series of new cyrhetrenyl and ferrocenylimines complexes derived from 5-nitrofurane were designed, synthesized and characterized. The 1H and 13C NMR spectra indicate that these compounds adopt an anti-(E) conformation in solution, and confirmed for 1b by the X-ray crystal crystallography. The electronic effects of cyrhetrenyl (1b) and ferrocenyl (1a) bound directly to nitrogen have been correlated with the chemical shift of the iminic carbon. The trypanocidal activity (Tulahuen strain of Trypanosoma cruzi) of these compounds has been studied with respect to the substituent on the nitrogen atom of the 5-nitrofurfurylideneamino pharmacophore. Even though all the resulting derivatives were less active than Nifurtimox, the cyrhetrenyl complex (1b), compared with ferrocenyl (1a) or purely organic (4a and 4b) analogues, was more efficient as antichagasic agent. This result is likely due to the enhanced lipophilic character of the molecules or from a possible synergy between the cyrhetrenyl and 5-nitrofurane groups.
Site-selective cation-π interaction as a way of selective recognition of the caesium cation using sumanene-functionalized ferrocenes
Kasprzak, Artur,Sakurai, Hidehiro
supporting information, p. 17147 - 17152 (2019/12/04)
The first sumanene-ferrocene probes for efficient and selective caesium cation (Cs+) recognition are reported. The working mechanism of the sumanene moiety as the sensing unit was based on the site-selective cation-π interaction in its neutral state. The interactions with Cs+ were characterized by high association constant values together with low limits of detection.
