1333379-39-7Relevant articles and documents
GELATINASE INHIBITORS AND PRODRUGS
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Paragraph 0246; 0247; 0248, (2013/03/26)
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological
Selective water-soluble gelatinase inhibitor prodrugs
Gooyit, Major,Lee, Mijoon,Schroeder, Valerie A.,Ikejiri, Masahiro,Suckow, Mark A.,Mobashery, Shahriar,Chang, Mayland
experimental part, p. 6676 - 6690 (2011/12/02)
SB-3CT (1), a selective and potent thiirane-based gelatinase inhibitor, is effective in animal models of cancer metastasis and stroke; however, it is limited by poor aqueous solubility and extensive metabolism. We addressed these issues by blocking the pr