133338-58-6

Basic information

• Product Name: N(2)-(3,4-dichlorobenzyl)guanine
• Synonyms: N(2)-(3,4-dichlorobenzyl)guanine
• CAS NO: 133338-58-6
• Molecular Formula: C₁₂H₉Cl₂N₅O
• Molecular Weight: 310.13876
• Mol File: 133338-58-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 602.8°Cat760mmHg
• Flash Point: 318.4°C
• Appearance: /
• Density: 1.72g/cm³
• Vapor Pressure: 1.74E-14mmHg at 25°C
• Refractive Index: 1.781
• CAS DataBase Reference: N(2)-(3,4-dichlorobenzyl)guanine(CAS DataBase Reference)
• NIST Chemistry Reference: N(2)-(3,4-dichlorobenzyl)guanine(133338-58-6)
• EPA Substance Registry System: N(2)-(3,4-dichlorobenzyl)guanine(133338-58-6)

Safety Data

• Hazardous Substances Data: 133338-58-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9Cl2N5O/c13-7-2-1-6(3-8(7)14)4-15-12-18-10-9(11(20)19-12)16-5-17-10/h1-3,5H,4H2,(H3,15,16,17,18,19,20)

Upstream product

• 500797-82-0 2-bromohypoxanthine 
• 102-49-8 3,4-dichlorobenzyl amine 

Downstream Products

• 579487-42-6 2-(3,4-dichloro-benzylamino)-7-(4-iodo-butyl)-1,7-dihydro-purin-6-one 
• 579486-77-4 7-(4-Hydroxybutyl)-2-(3,4-dichlorobenzylamino)-6-oxopurine 
• 579486-80-9 7-(5-acetoxypentyl)-2-(3,4-dichlorobenzylamino)-6-oxopurine 
• 579486-76-3 7-(4-Acetoxybutyl)-2-(3,4-dichlorobenzylamino)-6-oxopurine 

Relevant articles and documents

Purine and isosteric antibacterial compounds

The invention features 2,7-disubstituted purines and their isosteres such as the corresponding 3-deazapurines and 3-deaza-8-azapurines. The compounds disclosed herein have potent anti-microbial, e.g., anti-bacterial and anti-mycoplasmal properties. The compounds described herein inhibit DNA polymerase IIIC and DNA polymerase IIIE species; the compounds thus inhibit the growth of bacteria and mycoplasmata. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial or mycoplasmal infections, e.g., in eukaryotic cell cultures, animals, or humans.