1333395-36-0

Basic information

• Product Name: 3-[(E)-(2-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE
• Synonyms: 3-[(E)-(2-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE
• CAS NO: 1333395-36-0
• Molecular Formula: C16H11ClO2
• Molecular Weight: 270.71
• Mol File: 1333395-36-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[(E)-(2-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(E)-(2-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE(1333395-36-0)
• EPA Substance Registry System: 3-[(E)-(2-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE(1333395-36-0)

Safety Data

• Hazardous Substances Data: 1333395-36-0(Hazardous Substances Data)

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 89-98-5 2-chloro-benzaldehyde 
• 108-73-6 3,5-dihydroxyphenol 
• 1126-20-1 2-allyloxyphenol 
• 533-58-4 2-Iodophenol 
• 1507-92-2 o-chlorocinnamyl chloride 

Relevant articles and documents

A Convenient Palladium-Catalyzed Carbonylative Synthesis of (E)-3-Benzylidenechroman-4-ones

A convenient palladium-catalyzed carbonylation reaction for the efficient synthesis of (E)-3-benzylidenechroman-4-ones has been developed. Using TFBen as a solid CO source, a range of substituted (E)-3-benzylidenechroman-4-ones were prepared in moderate to good yields with 2-iodophenols and allyl chlorides as the substrates. Additionally, substituted quinolin-4(1H)-ones can also be obtained with 2-iodoaniline as the starting material.

Synthesis of rigid analogues of flavone by intramolecular heck reaction

A novel concise method to synthesize rigid analogues of flavone by an intramolecular Heck reaction with wide substrate scope was developed. The key intermediates 3-(2-bromobenzyl)-4H-chromen-4-ones were prepared easily in two steps. Most compounds were obtained with moderate to good yields (34-90?% yield, 19 examples). As the title reaction shows, rigid analogues of flavone were synthesized by an intramolecular Heck reaction from 3-(2-bromobenzyl)-4H-chromen-4-ones, which could be prepared easily in two steps. Most compounds were obtained with moderate to good yields.

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

A series of 3-benzylidene-4-chromanones 1a-l were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the