1333425-52-7Relevant academic research and scientific papers
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement
Moss, Neil,Xiong, Zhaoming,Burke, Mike,Cogan, Derek,Gao, Donghong A.,Haverty, Kathleen,Heim-Riether, Alexander,Hickey, Eugene R.,Nagaraja, Raj,Netherton, Matthew,O'Shea, Kathy,Ramsden, Philip,Schwartz, Racheline,Shih, Daw-Tsun,Ward, Yancey,Young, Erick,Zhang, Qing
, p. 7189 - 7193 (2013/01/15)
This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of this class of inhibitors. In addition, we put the unique characteristics of this class of compounds into perspective with other classes of cathepsin S inhibitors.
