1333430-91-3Relevant academic research and scientific papers
Divergent enantioselective total synthesis of siphonarienal, siphonarienone, and pectinatone
Yadav, Jhillu Singh,Chary, D. Narasimha,Yadav, Nagendra Nath,Sengupta, Sandip,Subba Reddy, Basi V.
, p. 1968 - 1977 (2013)
A divergent synthesis of siphonarienal, siphonarienone, and pectinatone has been achieved from a common precursor 4, which was synthesized by using an enzymatic desymmetrization approach. The major key steps involved were Grignard reaction, Wittig reactio
Enantioselective total synthesis of (+)-vittatalactone
Yadav, Jhillu S.,Yadav, Nagendra Nath,Srinivasa Rao,Subba Reddy,Al Ghamdi, Ahmad Al Khazim
, p. 4603 - 4608 (2011/10/03)
An enantioselective asymmetric total synthesis of (+)-vittatalactone has been accomplished employing enzymatic desymmetrization approach to create two methyl chiral centres. Other key steps involved are Wittig reaction, Evan's asym metric alkylation, hydroboration, TEMPO-BAIB-mediated selective oxidation of 1, 3-diol and lactonization mediated by p-toluenesulfonyl chloride. The total synthesis was achieved by a linear synthetic sequence with an overall yield of 11.8%.
