1333475-98-1Relevant academic research and scientific papers
Asymmetric synthesis of quaternary α-amino acid derivatives and their fluorinated analogues
Fustero, Santos,Sanchez-Rosello, Maria,Baez, Claribel,Del Pozo, Carlos,Garcia Ruano, Jose L.,Aleman, Jose,Marzo, Leyre,Parra, Alejandro
, p. 559 - 573 (2012/06/01)
In this work, we describe the asymmetric synthesis of a series of fluorinated and non-fluorinated quaternary α-amino acid derivatives. This methodology involves the diastereoselective addition of chiral 2-p-tolylsulfinyl benzylcarbanions to either imines containing a 2-furyl moiety or trifluoromethyl α-imino esters. Synthetic practicality of this method is demonstrated by short (two-steps) and convenient preparation of 2-(trifluoromethyl)indoline-2-carboxylates.
