1333481-74-5Relevant academic research and scientific papers
Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase
Yan, Yugang,Chen, Xueying,Yang, Xinying,Zhang, Jian,Xu, Wenfang,Zhang, Yingjie
, p. 6632 - 6640 (2015/10/19)
Compounds 10 (ND-322) and 15 (ND-364) are potent selective inhibitors for gelatinases, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9). However, both of them are racemates. Herein we report facile synthesis of optically active (R)-
GELATINASE INHIBITORS AND PRODRUGS
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, (2013/03/26)
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The disease, disorder, or condition can include, for example, stroke, neurological
Selective water-soluble gelatinase inhibitor prodrugs
Gooyit, Major,Lee, Mijoon,Schroeder, Valerie A.,Ikejiri, Masahiro,Suckow, Mark A.,Mobashery, Shahriar,Chang, Mayland
experimental part, p. 6676 - 6690 (2011/12/02)
SB-3CT (1), a selective and potent thiirane-based gelatinase inhibitor, is effective in animal models of cancer metastasis and stroke; however, it is limited by poor aqueous solubility and extensive metabolism. We addressed these issues by blocking the pr
