1333483-14-9

Basic information

• Product Name: N-methyll-N-(phenylethylnyl)methanesulfonamide
• Synonyms: N-methyll-N-(phenylethylnyl)methanesulfonamide
• CAS NO: 1333483-14-9
• Molecular Weight: 209.269
• Mol File: 1333483-14-9.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: N-methyll-N-(phenylethylnyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyll-N-(phenylethylnyl)methanesulfonamide(1333483-14-9)
• EPA Substance Registry System: N-methyll-N-(phenylethylnyl)methanesulfonamide(1333483-14-9)

Safety Data

• Hazardous Substances Data: 1333483-14-9(Hazardous Substances Data)

Upstream product

• 1184-85-6 N-methylmethane sulphonamide 
• 536-74-3 phenylacetylene 
• 932-87-6 1-Bromo-2-phenylacetylene 

Downstream Products

• 1357012-35-1 N-(4-(3,4-dimethoxyphenyl)-3,4-dihydronaphthalen-2-yl)-N-methylmethanesulfonamide 
• 1357012-32-8 N-methyl-N-(3-phenylnaphthalen-2-yl)methanesulfonamide 
• 1357012-36-2 N-(4-(2,4-dimethoxyphenyl)-3,4-dihydronaphthalen-2-yl)-N-methylmethanesulfonamide 
• 1609958-88-4 N-methyl-2-phenyl-2-(phenylthio)-N-methanesulfonylpent-4-enamide 

Relevant articles and documents

A Unified Approach for Divergent Synthesis of Heterocycles via TMSOTf-Catalyzed Formal [3+2] Cycloaddition of Electron-Rich Alkynes

We present a synthetic protocol for the construction of polysubstituted five-membered heterocycles via TMSOTf-catalyzed formal [3+2] cycloaddition of electron-rich alkynes, which features free from any metal, atom economy and water as the main by-product. Furthermore, alkenyl ether adduct has been verified as the key intermediate. Notably, by utilizing this approach, we can synthesize a broad range of polysubstituted furans, thiophenes and pyrroles, and extend this transformation to deliver fused-polyheterocycles. This reaction can be achieved on a gram scale and the corresponding products are intermediates for producing diverse potentially useful scaffolds. (Figure presented.).

Acid-catalyzed [2 + 2 + 2] cycloaddition of two cyanamides and one ynamide: Highly regioselective synthesis of 2,4,6-triaminopyrimidines

Triflic acid (10 mol%) catalyzes the highly regioselective [2 + 2 + 2] cycloaddition between two cyanamides and one ynamide to grant the 2,4,6-triaminopyrimidine core. The developed synthetic method is effective for the preparation of a family of the diversely substituted heterocyclic products (30 examples; yields up to 94%). The synthesis can be easily scaled up and conducted in gram quantities. As demonstrated by the post-functionalizations involving the amino-substituents, the obtained heterocycles represent a useful platform for the construction of miscellaneous pyrimidine-based frameworks. The performed density functional theory calculations verified a particular role of H+, functioning as an electrophilic activator, in the regioselectivity of the cycloaddition.

Catalyst-Free [4+2] Cycloaddition of Ynamides with 2-Halomethyl Phenols to Construct 2-Amino-4 H-Chromenes and α-Halo Enamides Simultaneously

We report the development of a facile protocol for the [4+2] cycloaddition of ynamides and 2-halomethyl phenols to afford the corresponding 2-amino-4H-chromenes and α-halo enamides under catalyst-free conditions. The reaction proceeds under mild condition