1333494-54-4Relevant academic research and scientific papers
Synthesis of the anti-melanogenic glycerol fatty acid ester isolated from the tuber-barks of colocasia antiquorum var esculenta
Zhu, Shijun,Wu, Yikang
, p. 261 - 264 (2014/02/14)
(2′S)-1-O-9-Oxo-(10E,12E)-octadecadienoyl glycerol, a natural anti-melanogenic monoglyceride, is synthesized for the first time. The chiral pool based route employed not only confirms the absolute configuration, but also illustrates the first synthetic entry to the (E,E)-diene keto acid, which is another molecule of biological importance. The confusion caused by the misinterpreted 1H NMR spectroscopic data for the (E,E)-diene motif in the literature is discussed. The first unequivocal piece of evidence for the assigned (12E) configuration is also presented. Georg Thieme Verlag Stuttgart, New York.
