1333502-06-9Relevant academic research and scientific papers
Stereocontrolled solid-phase synthesis of phosphorothioate oligoribonucleotides using 2′-O-(2-cyanoethoxymethyl)-nucleoside 3′-O-oxazaphospholidine monomers
Nukaga, Yohei,Yamada, Kohei,Ogata, Toshihiko,Oka, Natsuhisa,Wada, Takeshi
, p. 7913 - 7922 (2012)
A method for the synthesis of P-stereodefined phosphorothioate oligoribonucleotides (PS-ORNs) was developed. PS-ORNs of mixed sequence (up to 12mers) were successfully synthesized by this method with sufficient coupling efficiency (94-99%) and diastereose
METHOD FOR PREPARING RIBONUCLEOSIDE PHOSPHOROTHIOATE
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Paragraph 0060; 0064; 0065; 0066, (2013/07/25)
A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2′-hydroxyl group of RNA.
