133352-98-4

Basic information

• Product Name: STEM CELL FACTOR, HUMAN
• Synonyms: RHSCF;RECOMBINANT HUMAN SCF;REC STEM CELL FACTOR (HUMAN);REC SCF (HUMAN);SCF, HUMAN;STEM CELL FACTOR, HUMAN;STEM CELL FACTOR, HUMAN, RECOMBINANT;STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI
• CAS NO: 133352-98-4
• Molecular Weight: 0
• Mol File: 133352-98-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: −20°C
• CAS DataBase Reference: STEM CELL FACTOR, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: STEM CELL FACTOR, HUMAN(133352-98-4)
• EPA Substance Registry System: STEM CELL FACTOR, HUMAN(133352-98-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 133352-98-4(Hazardous Substances Data)

Usage

General Description

The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32.

Biochem/physiol Actions

Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors.