133360-01-7

Basic information

• Product Name: Thiophene, 2,3,4,5-tetrafluorotetrahydro- (9CI)
• Synonyms: Thiophene, 2,3,4,5-tetrafluorotetrahydro- (9CI)
• CAS NO: 133360-01-7
• Molecular Formula: C₄H₄F₄S
• Molecular Weight: 160.1331728
• Product Categories: HALIDE
• Mol File: 133360-01-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiophene, 2,3,4,5-tetrafluorotetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2,3,4,5-tetrafluorotetrahydro- (9CI)(133360-01-7)
• EPA Substance Registry System: Thiophene, 2,3,4,5-tetrafluorotetrahydro- (9CI)(133360-01-7)

Safety Data

• Hazardous Substances Data: 133360-01-7(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 

Relevant articles and documents

THE FLUORINATION OF SIMPLE FIVE-MEMBERED HETEROAROMATIC COMPOUNDS WITH ELEMENTAL FLUORINE

The reaction of elemental fluorine with five-membered heteroaromatics under controlled conditions proceeds cleanly, yielding major substitution products in the case of thiophene (1) and N-methylpyrrole (2) or 1,4-addition products in the case of furan (3), while pyrrole (4) gives only tars.The site of fluorine substitution on N-methylpyrrole remarkably favours the β carbon atoms by a factor of ca. 3 over the α carbons.The α/β substitution ratio for 1 (1.9) and 2 (0.28) and the intermolecular reactivity order N-methylpyrrole > thiophene > benzene agrees with a polar electrophilic substitution mechanism.Also the predominantly syn 1,4-addition to furan conforms to the polar syn addition of F2 to double bonds.