133365-46-5

Upstream product

• 56654-49-0 2-(2-hydroxy-ethyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 133364-91-7 2-[2-[4-[Bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one Hydrochloride 
• 133365-01-2 2-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-1,2,4-triazolo[4,3-a]pyridin-3-one 

Relevant academic research and scientific papers

Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression

A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compound and methods for treating disorders of the serotonin-affected neurological systems u

Heterocyclic compound having serotonine 2-receptor antagonistic activity

A heterocyclic compound represented by formula (I): STR1 wherein R1 represents a hydrogen atom, an alkyl group, an aryl group which may be substituted with one or more substituents selected from the group consisting of a halogen atom, an alkoxy group, an alkyl group and a trihalogenomethyl group; λ represents 0 or 1; ring A represents a 6 membered heterocyclic ring containing the nitrogen atom shared with the triazine ring and which may contain one or more double bonds; Y represents a substituted or unsubstituted alkylene group having 1 to 15 carbon atoms; and Q represents a group represented by formula (II): STR2 wherein R2, R3, R4 and R5 are represented by substituents disclosed herein; or salt thereof, and intermediates therefor are described. The compound of formula (I) or salt thereof exhibit selective serotonin 2-receptor antagonistic activity and are useful for the prevention or treatment of circulatory diseases, e.g., ischemic heart diseases, cerebral vessel disturbances, and peripheral circulation disturbances.