133374-73-9Relevant academic research and scientific papers
Direct Conversion of N-Alkoxy β-Lactams to Carbapenams: Application to the Synthesis of the Bicyclic PS-5 Keto Ester
Williams, Matthew A.,Hsiao, Chi-Nung,Miller, Marvin J.
, p. 2688 - 2694 (1991)
The synthesis and direct conversion of N-alkoxy β-lactams to the carbapenam ring system is described.This novel cyclization apparently proceeds by initial carbene-mediated ylide formation with concomitant rearrangement.The title reaction is applied to the construction of the methyl ester of the bicyclic β-lactam precursor of PS-5.
