133377-40-9Relevant academic research and scientific papers
Copper-Catalyzed Synthesis of α-Trifluoromethylacrylates from Trifluoroborylacrylates via Stereoretentive Radical Trifluoromethylation
Jos, Swetha,Santos, Webster L.
, p. 425 - 430 (2021)
We report the synthesis of α-trifluoromethylacrylates from α-trifluoroborylacrylates via a stereoretentive radical trifluoromethylation with inexpensive reagents NaSO2CF3 and TBHP at room temperature. Under these conditions, a wide substrate scope afforded the (E)-diastereomer exclusively in moderate to good yield. The utility of the reaction products is demonstrated in the synthesis of phenyl-4H-pyran, a potent and selective class of IKCa channel blockers. (Figure presented.).
