133379-33-6Relevant academic research and scientific papers
Method for the preparation of erythro vicinal amino-alcohols
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, (2008/06/13)
The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.
Transimination. Conversion of Nitriles into Secondary Amines in a One-Pot Reaction.
Brussee, J.,Gen, A. van der
, p. 25 - 26 (2007/10/02)
Transimination has been used as a key step into convenient, highly erythro selective, one-pot synthesis of N-substituted β-ethanolamines from (R)-(+)--benzeneacetonitrile (OTBS-mandelonitrile).
