133379-60-9Relevant academic research and scientific papers
Synthesis and antiradiation activity of some sulfur containing thiophene derivatives
Hassan,Ghorab,Nassar
, p. 77 - 86 (1998)
Condensation of 2-(2,2-dicyano-1-methylvinyl)thiophene (2) with phenylhydrazine furnished the corresponding 2-(1-phenylhydrazonoethyl)-thiophene (4). Compound (4) was obtained also via reaction of (1) with phenylhydrazine. Reaction of (2) with amines gave 2-(2,2-dicyano-1-ethylamino or benzylamino-1 methylethyl)thiophene (5a,b). Treatment of (2) with elemental sulfur yielded directly the cyclised product 2-(5-amino-4-cyano-3-thienyl)thiophene (6). On the other hand refluxing (2) in pyridine with carbon disulfide gave the pyridine-1,3-dithione derivative (7). Condensation of (2) with phenyl isocyanate and/or phenyl isothiocyanate afforded 6-amino-4-(2-thienyl)-1,2-dihydro-2-oxo-1-phenylpyridine-5-carbonitrile (9) and/or 5-(2-thienyl)-2,7-dithioxo-3,8-N-phenyl-1,2,3,7,8-pentahydropyrido[2,3-d] pyrimidine-4-imine (11). Also the dicyano derivative (2) when reacted with cinnamonitrile (12) afforded the 2-(3-amino-2,4-dicyano-5-arylphenyl)-thiophenes (15a-d). Conversion of (15b) into the polyazanaphthalene (17) and (18) was affected via cyclocondensation with phenyl isocyanate and/or phenyl isothiocyanate. Compound (15a) showed promising antiradiation activity.
Nitriles in Organic Synthesis: Synthesis of Aromatic Amines, Aminopyridines, PyridoPyridine and PyridoPyrimidine Derivatives
El-Taweel, F. M.
, p. 762 - 766 (2007/10/02)
The reaction of the α-arylethylidenemalononitrile derivatives 1a,c with piperonylidenemalononitrile (2a) and with ethyl piperonylidenecyanoacetate (2b) yield 1-amino-3,5-diaryl-2,6-benzenedicarbonitrile (3a,c).Phenylaminopyridines 5a,b were obtained from
