133382-30-6

Basic information

• Product Name: ethyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: Ethyl-3-hydroxy-1-oxa-8-azaspiro[4.5]decan-8-carboxylat
• CAS NO: 133382-30-6
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.2729
• Mol File: 133382-30-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.439°C at 760 mmHg
• Flash Point: 184.488°C
• Density: 1.222g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: ethyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(133382-30-6)
• EPA Substance Registry System: ethyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(133382-30-6)

Safety Data

• Hazardous Substances Data: 133382-30-6(Hazardous Substances Data)

Upstream product

• 133405-47-7 1-(ethoxycarbonyl)-4-hydroxy-4-(2,3-dihydroxypropyl)piperidine 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Cyclic Ether Synthesis via Palladium-Catalyzed Directed Dehydrogenative Annulation at Unactivated Terminal Positions

Here, a palladium-catalyzed functionalization of unactivated sp3 C-H bonds with internal alcohol nucleophiles is described. Directed by an oxime-masked alcohol, annulation chemoselectively occurs at the β position, leading to a range of aliphatic cyclic ethers with four- to seven-membered rings. Tethered primary, secondary, and tertiary free hydroxyl groups can all react to give the corresponding cyclized products. In addition, benzyl and silyl protected alcohols can also be directly coupled. An sp3 C-H activation/intramolecular SN2 pathway was proposed.

SPIROFURANE DERIVATIVES

Compounds of general formula I, STR1 wherein R 1 represents hydrogen or alkyl C 1-3,R 2 represents hydrogen or alkyl C 1-6,n and m are integers from 1 to 3, provided that n+m=4, andone of X and Y represents CH. sub.2 and the other represents CHR 3, C=O, C=CHR 4 or C. dbd.NR 5, in whichR 3, R. sup.4 and R 5 are as defined in the specification, and their salts are useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptors. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome, and also as analgesic agents for use in the treatment of severe painful conditions such as rheumatism, arthritis, and terminal illness.