133390-72-4

Upstream product

• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 133390-69-9 3-[1-(4-Methoxy-phenyl)-5-thiophen-2-yl-1H-pyrazol-3-yl]-propionic acid 
• 126724-39-8 4,6-Dioxo-6-(2-thienyl)hexanoic acid 
• 88-15-3 2-Acetylthiophene 

Relevant academic research and scientific papers

Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same

N-1 and C-5 heterocyclic pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.

The regioselective synthesis of tepoxalin, 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-me thylpropanamide and related 1,5-diarylpyrazole anti-inflammatory agents

Tepoxalin, a potent anti-inflammatory agent, and its analogs can be synthesized by condensing an appropriate arylhydrazine hydrochloride and a 6-aryl-4,6-dioxohexanoic acid in alcohol with a base catalyst. These diarylpyrazolylpropanoic acids can be converted to their N-methylhydroxamic acids by generating the requisite acid chloride, and allowing it to react with N-methylhydroxylamine.