133392-32-2Relevant academic research and scientific papers
Stereoselective Synthesis of Optically Active 2-Hydroxymandelic Acids and Esters via Friedel-Crafts Coordinated Reaction: Crystal Structure of Chiral Dichloro[2-(1-oxido-1-menthoxycarbonylmethyl)-4-methoxyphenoxido-O,O,O] titanium?
Bigi, Franca,Bocelli, Gabriele,Maggi, Raimondo,Sartori, Giovanni
, p. 5004 - 5009 (1999)
Highly diastereoselective hydroxyalkylation of phenols with chiral glyoxylates was performed. Hydrolysis or reduction of the esters 3 afforded 2-hydroxymandelic acids 6 and diols 5 in high yields and enantiomeric pure form. Mechanistic evidence of chelati
HIGHLY REGIO- AND DIASTEREOSELECTIVE FRIEDEL-CRAFTS ALKYLATION OF PHENOLS. SYNTHESIS OF 2-HYDROXYMANDELIC ESTERS
Bigi, F.,Casnati, G.,Sartori, G.,Dalprato, C.,Bortolini, R.
, p. 861 - 864 (2007/10/02)
Ortho-hydroxyalkylation of phenol substrates was performed via coordinative complexes of metal phenolates with chiral glyoxylates: optically active 2-hydroxymandelic esters have been obtained with good yields and very high diastereoselectivity (up to 94pe
