1333992-29-2

Upstream product

• 1173243-10-1 3'-azido-6-N-[(di-n-butylamino)methylene]-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-adenosine 
• 117830-89-4 Fmoc-Gly-OBt 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 

Downstream Products

• 1333992-34-9 6-N-[(di-n-butylamino)methylene]-3'-{[N-(9-fluorenyl)methoxycarbonyl-glycyl]amino}-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-O-[1,6-dioxo-6-(pentafluorophenyloxy)hexyl]-β-D-adenosine 

Relevant academic research and scientific papers

Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs

RNA-peptide conjugates that mimic amino acid-charged tRNAs and peptidyl-tRNAs are of high importance for structural and functional investigations of ribosomal complexes. Here, we present the synthesis of glycyl-, alanyl-, and isoleucyladenosine modified solid supports that are eligible for the synthesis of stable 3′-aminoacyl- and 3′-peptidyl-tRNA termini with an amide instead of the natural ester linkage. The present work significantly expands the range of accessible peptidyl-tRNA mimics for ribosomal studies.