1333996-60-3Relevant articles and documents
Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P1 and S1P5 receptors efficacious at low oral dose
Demont, Emmanuel H.,Arpino, Sandra,Bit, Rino A.,Campbell, Colin A.,Deeks, Nigel,Desai, Sapna,Dowell, Simon J.,Gaskin, Pam,Gray, James R. J.,Harrison, Lee A.,Haynes, Andrea,Heightman, Tom D.,Holmes, Duncan S.,Humphreys, Philip G.,Kumar, Umesh,Morse, Mary A.,Osborne, Greg J.,Panchal, Terry,Philpott, Karen L.,Taylor, Simon,Watson, Robert,Willis, Robert,Witherington, Jason
, p. 6724 - 6733 (2011/12/04)
2-Amino-2-(4-octylphenethyl)propane-1,3-diol 1 (fingolimod, FTY720) has been recently marketed in the United States for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). Its efficacy has been primarily linked to the agonism on