133412-71-2

Upstream product

• 135851-05-7 3-(3-Benzoyl-2-methyl-isothioureido)-4-cyclohex-1-enyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 135851-03-5 ((Z)-2-Cyano-2-cyclohex-1-enyl-vinylamino)-acetic acid methyl ester 
• 133412-68-7 3-Amino-4-cyclohex-1-enyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 133412-65-4 Cyclohexen-1-yl-cyanacetaldehyd 
• 6975-71-9 1-cyclohexenylacetonitrile 
• 133412-69-8 3-(3-Benzoyl-thioureido)-4-cyclohex-1-enyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 135851-04-6 3-Amino-4-cyclohex-1-enyl-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester 

Relevant academic research and scientific papers

Process for the preparation of 9-deazaguanine derivatives

Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine

Alicyclic and heteroalicyclic derivatives of 9-deazaguanine (2-amino-1,5- dihydro-4H-pyrrolo[3,2-d][pyrimidin-4-one) are, with one exception, potent inhibitors of purine nucleoside phosphorylase (PNP) equaling the corresponding 9-arylmethyl derivatives pr