1334127-13-7

Basic information

• Product Name: 1-(4-methoxybenzyl)-3-(6-nitrobenzo[d]thiazol-2-yl)urea
• Synonyms: 1-(4-methoxybenzyl)-3-(6-nitrobenzo[d]thiazol-2-yl)urea
• CAS NO: 1334127-13-7
• Molecular Weight: 358.378
• Mol File: 1334127-13-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzyl)-3-(6-nitrobenzo[d]thiazol-2-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzyl)-3-(6-nitrobenzo[d]thiazol-2-yl)urea(1334127-13-7)
• EPA Substance Registry System: 1-(4-methoxybenzyl)-3-(6-nitrobenzo[d]thiazol-2-yl)urea(1334127-13-7)

Safety Data

• Hazardous Substances Data: 1334127-13-7(Hazardous Substances Data)

Upstream product

• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 100-01-6 4-nitro-aniline 
• 2393-23-9 4-methoxy-benzylamine 
• 56651-60-6 4-methoxybenzyl isocyanate 

Relevant articles and documents

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation

Glycogen synthase kinase 3 (GSK-3)has become known for its multifactorial involvement in the pathogenesis of Alzheimer's disease. In this study, a benzothiazole- and benzimidazole set of 1-aryl-3-(4-methoxybenzyl)ureas were synthesised as proposed Cys199-targeted covalent inhibitors of GSK-3β, through the incorporation of an electrophilic warhead onto their ring scaffolds. The nitrile-substituted benzimidazolylurea 2b (IC50 = 0.086 ± 0.023 μM)and halomethylketone-substituted benzimidazolylurea 9b (IC50 = 0.13 ± 0.060 μM)displayed high GSK-3β inhibitory activity, in comparison to reference inhibitor AR-A014418 (1, IC50 = 0.072 ± 0.043)in our assay. The results suggest further investigation of 2b and 9b as potential covalent inhibitors of GSK-3β, since a targeted interaction might provide improved kinase-selectivity.