1334159-63-5Relevant academic research and scientific papers
Copper-mediated selective aerobic oxidative C3-cyanation of indoles with DMF
Xiao, Jing,Li, Qiang,Chen, Tieqiao,Han, Li-Biao
supporting information, p. 5937 - 5940 (2015/11/02)
Under an oxygen atmosphere, the copper-mediated direct C3-cyanation of indole C-H bonds, using cheap and safe DMF as a CN source, took place selectively to produce the corresponding C3-cyanoindoles in good yields. A possible mechanism for this selective cyanation was proposed.
Synthesis of 3-cyanoindole derivatives mediated by copper(I) iodide using benzyl cyanide
Yuen, On Ying,Choy, Pui Ying,Chow, Wing Kin,Wong, Wing Tak,Kwong, Fuk Yee
, p. 3374 - 3378 (2013/06/26)
Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.
Lewis acid catalyzed direct cyanation of indoles and pyrroles with N-cyano-N-phenyl-p-toluenesulfonamide (NCTS)
Yang, Yang,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 5608 - 5611 (2011/12/03)
BF3?OEt2-catalyzed direct cyanation of indoles and pyrroles using a less toxic, bench-stable, and easily handled electrophilic cyanating agent N-cyano-N-phenyl-para-toluenesulfonamide (NCTS) affords 3-cyanoindoles and 2-cyanopyrroles in good yields with excellent regioselectivity. The substrate scope is broad with respect to indoles and pyrroles.
