1334177-86-4

Basic information

• Product Name: Mal-PEG8-COOH
• Synonyms: Mal-PEG8-COOH;1-Maleimido-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-aza-hentriacontan-31-oic acid;Mal-amido-PEG8-acid;Maleimide-PEG8-propionic acid;31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic Acid;Mal-NH-PEG8-COOH
• CAS NO: 1334177-86-4
• Molecular Formula: C₂₆H₄₄N₂O₁₃
• Molecular Weight: 592.63316
• EINECS: -0
• Product Categories: PEGylation Reagents;Monodispersed PEG Derivatives
• Mol File: 1334177-86-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 747.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: Mal-PEG8-COOH(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG8-COOH(1334177-86-4)
• EPA Substance Registry System: Mal-PEG8-COOH(1334177-86-4)

Safety Data

• Hazardous Substances Data: 1334177-86-4(Hazardous Substances Data)

Usage

Description

Mal-amido-PEG8-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic Acid is reactant in the light-induced endosomal lysis events in fibroblast, normal, and carcinoma cell lines using a colloidal mesoporous silica (CMS) nanoparticle.