1334212-43-9

Basic information

• Product Name: 3,5-bis(3-fluorophenyl)-1,2,4-thiadiazole
• Synonyms: 3,5-bis(3-fluorophenyl)-1,2,4-thiadiazole
• CAS NO: 1334212-43-9
• Molecular Weight: 274.294
• Mol File: 1334212-43-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3,5-bis(3-fluorophenyl)-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(3-fluorophenyl)-1,2,4-thiadiazole(1334212-43-9)
• EPA Substance Registry System: 3,5-bis(3-fluorophenyl)-1,2,4-thiadiazole(1334212-43-9)

Safety Data

• Hazardous Substances Data: 1334212-43-9(Hazardous Substances Data)

Upstream product

• 403-54-3 m-Fluorobenzonitrile 
• 72505-20-5 3-fluorobenzene-1-carbothioamide 
• 31253-11-9 methyl 2-bromo-2-cyanoacetate 

Relevant articles and documents

Aerobic Visible-Light Induced Intermolecular S?N Bond Construction: Synthesis of 1,2,4-Thiadiazoles from Thioamides under Photosensitizer-Free Conditions

Aerobic visible-light induced intermolecular S?N bond construction has been achieved without the addition of photosensitizer, metal, or base. With this strategy, 1,2,4-thiadiazoles can be obtained from thioamides. Preliminary mechanistic investigation suggested that the excited state of thioamides undergoes a single-electron-transfer (SET) process to afford thioamidyl radicals, which can be further transformed into a 1,2,4-thiadiazole through desulfurization and oxidative cyclization. The reaction has good functional group tolerance and represents a green method for the construction of S?N bonds.

Novel method for electrochemically synthesizing 1, 2, 4 - thiadiazole compounds

The invention discloses a novel method for electrochemically synthesizing a 1,2,4-thiadiazole compound. Specifically, the novel method comprises the following steps: adding 0.5mmol of thioamide, 0.025mmol of ammonium iodide, 3mL of methanol and 3mL of ace

The facile and efficient organocatalytic platform for accessing 1,2,4-selenadiazoles and thiadiazoles under aerobic conditions

The first organocatalytic approach towards synthesis of rarely explored 1,2,4-selenadiazole and thiadiazole scaffolds have been devised using corresponding carboxamides as substrates. The transformations were realized using two distinct conditions in the presence of catalytic vitamin B3 or thiourea under aerobic conditions. Developed methods overcome the associated limitations of previous reported approaches and the desired products were obtained in high yields and selectivity without the formation of toxic side-products.