1334218-07-3Relevant academic research and scientific papers
Regioselective [2+2+2] Cycloaddition Reaction Using Allene-ynes with Simple Allenes under Nickel Catalysis
Arai, Shigeru,Izaki, Arisa,Amako, Yuka,Nakajima, Masaya,Uchiyama, Masanobu,Nishida, Atsushi
, p. 4882 - 4887 (2019)
A Ni-catalyzed [2+2+2] cycloaddition reaction between allene-ynes and various mono-, di- and tri-substituted allenes is described. This protocol effectively differentiates allenyl π components and shows broad substrate generality to give highly functionalized carbocycles. A DFT study played a key role in revealing a detailed reaction mechanism that controls site-, regio- and stereoselectivity, which are thought to originate in the substituent effect on π-bonds in the early transition state. (Figure presented.).
