1334230-07-7Relevant academic research and scientific papers
Cyclopropyl iminium activation: Reactivity umpolung in enantioselective organocatalytic reaction design
Sparr, Christof,Gilmour, Ryan
, p. 8391 - 8395 (2011/10/09)
Trick the iminium! The concept of cyclopropyl iminium activation for the organocatalytic desymmetrization of meso-cyclopropylcarbaldehydes is presented. A combination of nucleophilic and electrophilic chlorinating reagents leads to a formal addition of Cl2 across one of the cyclopropyl bonds giving access to 1,3-dichlorides in an enantioselective, catalytic fashion.
