1334238-32-2Relevant academic research and scientific papers
A chemo-enzymatic synthesis of optically active 1,1- diethoxyethyl(aminomethyl)phosphinates: Useful chiral building blocks for phosphinyl dipeptide isosteres
Yamagishi, Takehiro,Mori, Jun-Ichirou,Haruki, Terumitsu,Yokomatsu, Tsutomu
, p. 1358 - 1363 (2011/11/30)
The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl dipeptide isosteres.
