133430-71-4

Upstream product

• 831-30-1 5-(p-methoxyphenyl)dithia<1,2>cyclopenten-3-one 
• 18274-81-2 desmethyl anethole trithione 
• 532-11-6 anethole trithione 

Relevant academic research and scientific papers

Metabolism of anethole dithiolethione by rat and human liver microsomes: Formation of various products deriving from its o-demethylation and s-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways

A study of the metabolism of anethole dithiolethione (ADT, 5-(p-methoxyphenyl)-3H-1,2-dithiole-3-thione) by rat and human liver microsomes showed the formation of the corresponding S-oxide and the S-oxide of desmethyl-ADT (dmADT, 5-(p-hydroxyphenyl)-3H-1,

De-methylated anethol trisulfide derivative as well as preparation method and application thereof

The invention provides a de-methylated anethol trisulfide derivative as well as a preparation method and application thereof. The de-methylated anethol trisulfide derivative is a compound shown as a formula (I), wherein R1 and R2 are respectively or simul

DESMETHYLANETHOLE TRITHIONE DERIVATIVES FOR THE TREATMENT OF DISEASES LINKED TO MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) PRODUCTION

The present invention relates to desmethylanethole trithione ( AOX ) and derivatives thereof, especially derivatives of formula (I), for the prevention and treatment of diseases whose initiation and/or evolution relates to the production and effects of re

Assessment of the substituent constants of the -3-thioxo-l,2-dithiol-4- and -5-yl groups through pKa values measurements of 4 and 5-(hydroxy- or amino-phenyl)-l,2-dithiole-3-thiones in water at 298

The UV-VIS spectrophotometric assessment of the electronic substituent constants of the 3-thioxo-l,2-dithiol-4-and -5-yl and 3-oxo-l,2-dithiol-4- and -5-yl groups through pKa measurements in water of 4 and 5-(hydroxy or amino-phenyl)-1,2-dithiole-3-thiones and corresponding dithiolones has been performed. Linear free-enthalpy relationships based on pKa values of phenols and anilinium ions indicated a strong withdrawing effect for the 3-thioxo-l,2-dithiol-5-yl group by both an inductive and a resonance effect [?p- = 0.76, ?m = 0.44 (anilinium ions relationship) and ?p- = 0.97, ?m = 0.45 (phenols relationship)]. The corresponding 3-oxo group was slightly less attractive than the 3-thioxo one [?p- = 0.64 (anilinium ions) and ?p- = 0.78 (phenols)]. The 3-thioxo-l,2-dithiol-4-yl group and also its oxo analogue had only a weak withdrawing effect by an inductive effect (?p ca. ?p- ca.0.2) indicating a lack of conjugation between the dithiole and phenyl nuclei in 4-phenyldithiolethiones. The original 1,2-dithiole-3-thiones and 1,2-dithiol-3-ones used in correlations are described.