133430-90-7Relevant academic research and scientific papers
The Reaction of Ketone Alkylhydrazones with Phosphorus Trichloride and Methyl Acetoacetate: A Mild New Route to 2-Alkenylpyrazol-3(2H)-one Derivatives
Baccolini, Graziano,Sgarabotto, Paolo
, p. 34 - 35 (1991)
The title compounds have been synthesized by the one-pot reaction at room temperature of ketone alkylhydrazones, PCl3 and methyl acetoacetate; a single crystal X-ray structure determination of the minor isomer of one derivative permitted the assignment of its structure and showed the Z-configuration of the alkenyl group.
Synthesis of 2-Alkenylpyrazol-3(2H)-one Derivatives Under Mild Conditions
Baccolini, Graziano,Evangelisti, Daniele,Rizzoli, Corrado,Sgarabotto, Paolo
, p. 1729 - 1734 (2007/10/02)
The title compounds have been synthesized by a one-pot two-stage reaction of PCl3, ketone methylhydrazones and methyl acetoacetate.Both stages were carried out at room temperature and the corresponding 2-alkenyl-1,5-dimethylpyrazol-3(2H)-ones 5, which are an unknown series of pyrazolones, were obtained in good yields.Use of a variety of enolizable ketones has shown that the reaction always occurs with the predominance of the (E)-isomer.X-Ray structure determinations of an (E)- and a (Z)-derivative permitted the assignment of their structures.The aromaticity of these derivatives is discussed.
