1334320-38-5Relevant academic research and scientific papers
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors
Yan, Zi-Hong,Wu, Hai-Qiu,Chen, Wen-Xue,Wu, Yan,Piao, Hu-Ri,He, Qiu-Qin,Chen, Fen-Er,De Clercq, Erik,Pannecouque, Christophe
, p. 3220 - 3226 (2014/06/09)
A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker between wing I and the central pyrimidine ring was synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures. The two most promising compou
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs
Gu, Shuang-Xi,He, Qiu-Qin,Yang, Shi-Qiong,Ma, Xiao-Dong,Chen, Fen-Er,Clercq, Erik De,Balzarini, Jan,Pannecouque, Christophe
experimental part, p. 5117 - 5124 (2011/10/04)
A series of 26 diarylpyrimidines, characterized by the hydroxymethyl linker between the left wing benzene ring and the central pyrimidine, were synthesized and evaluated for in vitro anti-HIV activity. Most of the compounds exhibited moderate to excellent
