1334323-95-3

Upstream product

• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 1334323-96-4 (3S,5S)-benzyl 3-benzyl-5-(2-oxopropyl)morpholine-4-carboxylate 
• 1334324-30-9 (S,E)-benzyl (1-((4-oxopent-2-en-1-yl)oxy)-3-phenylpropan-2-yl)carbamate 
• 1334324-64-9 C₂₀H₂₃NO₃ 

Downstream Products

• 1334324-60-5 (4S,7S,8R,9aS)-4-benzyl-8-methyl-7-nitrooctahydropyrido[2,1-c][1,4]oxazin-8-ol 
• 1334324-76-3 1-((3R,5S)-5-benzylmorpholin-3-yl)propan-2-one 

Relevant academic research and scientific papers

Synthesis of substituted morpholines using stereodivergent aza-michael reactions catalyzed by Bronsted acids

A diastereoselective intramolecular aza-Michael reaction between N-Cbz carbamates and enones was studied. The investigation revealed that Bronsted acids with different strengths produce different diastereomers. The catalysts TfOH and TFA were used to generate differential outcomes in the aza-Michael reaction.

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts

An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) comp