133437-08-8

Basic information

• Product Name: 6-BENZYLAMINO-1-HEXANOL
• Synonyms: 6-BENZYLAMINO-1-HEXANOL;N-(6-HYDROXYHEXYL)BENZYLAMINE;6-(benzylamino)hexan-1-ol
• CAS NO: 133437-08-8
• Molecular Formula: C₁₃H₂₁NO
• Molecular Weight: 207.31194
• Mol File: 133437-08-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 95.6°C
• Appearance: /
• Density: 1.00
• Vapor Pressure: 7.95E-05mmHg at 25°C
• Refractive Index: 1.5220-1.5260
• CAS DataBase Reference: 6-BENZYLAMINO-1-HEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYLAMINO-1-HEXANOL(133437-08-8)
• EPA Substance Registry System: 6-BENZYLAMINO-1-HEXANOL(133437-08-8)

Safety Data

• Hazardous Substances Data: 133437-08-8(Hazardous Substances Data)

Usage

General Description

6-BENZYLAMINO-1-HEXANOL, also known as N-benzylhexanolamine, is a chemical compound with the molecular formula C13H19NO. It is a pale yellow liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has a wide range of potential applications in various industries, including the production of surfactants, lubricants, and corrosion inhibitors. 6-BENZYLAMINO-1-HEXANOL is also known for its potential therapeutic properties and has been studied for its potential use in the treatment of various medical conditions. Additionally, it is important to handle 6-BENZYLAMINO-1-HEXANOL with care, as it is a skin and eye irritant and may be harmful if ingested or inhaled.

InChI:InChI=1/C13H21NO/c15-11-7-2-1-6-10-14-12-13-8-4-3-5-9-13/h3-5,8-9,14-15H,1-2,6-7,10-12H2

Upstream product

• 821-09-0 n-Pent-4-enyl alcohol 
• 201230-82-2 carbon monoxide 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 130422-35-4 N-Benzyl-6-hydroxyhexanamide 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 4048-33-3 6-amino-1-hexanol 
• 113261-23-7 N-(hex-5-en-1-yl)benzamide 
• 33241-96-2 1-Benzyl-hexahydro-azepin-2-on 

Downstream Products

• 213771-45-0 tert-butyl benzyl(6-hydroxyhexyl)carbamate 
• 1396114-07-0 6-(((1H-pyrazol-1-yl)methyl)(benzyl)amino)hexan-1-ol 
• 1393923-08-4 tert-butyl-N-benzyl(6-bromohexyl)carbamate 
• 1393923-25-5 tert-butyl-N-benzyl(hex-5-en-1-yl)carbamate 
• 1000886-17-8 methyl-N-[2-{1-[benzyl(6-hydroxyhexyl)amino]heptyl}-4,4-dimethyl-1,3-oxazol-5(4H)-ylidene]glycinate 
• 213772-98-6 N-(N'-benzyl-N'-tert-butoxycarbonyl-6-aminohexyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid 
• 213772-78-2 [6-(benzyl-tert-butoxycarbonyl-amino)-hexyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester 
• 213772-41-9 6-[6-(N-tert-Butoxycarbonyl-N-phenylmethylamino)-hexylamino]-hexan-1-ol 

Relevant articles and documents

Sequential hydroaminomethylation/Pd-catalyzed hydrogenolysis as an atom efficient route to valuable primary and secondary amines

The facile synthesis of valuable primary and secondary amines is reported using a sequential procedure of hydroaminomethylation and Pd-catalyzed hydrogenolysis. The hydroaminomethylation reaction was catalyzed by a cationic Rh(I) iminopyridyl complex and the N-alkylated benzylamines were produced with high chemoselectivity, albeit as mixtures of linear and branched products. Performing the hydrogenolysis reaction using 10% Pd/C, provided access to valuable primary and secondary amines which have applications in the surfactant, pharmaceutical and polymer industries.

Acid promoted cyclodehydration of amino alcohols with amide acetal

A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.

A mild, palladium-catalyzed method for the dehydrohalogenation of alkyl bromides: Synthetic and mechanistic studies

We have exploited a typically undesired elementary step in cross-coupling reactions, β-hydride elimination, to accomplish palladium-catalyzed dehydrohalogenations of alkyl bromides to form terminal olefins. We have applied this method, which proceeds in excellent yield at room temperature in the presence of a variety of functional groups, to a formal total synthesis of (R)-mevalonolactone. Our mechanistic studies have established that the rate-determining step can vary with the structure of the alkyl bromide and, most significantly, that L2PdHBr (L = phosphine), an intermediate that is often invoked in palladium-catalyzed processes such as the Heck reaction, is not an intermediate in the active catalytic cycle.