133438-66-1

Basic information

• Product Name: JWH 200 2'-naphthyl isomer
• Synonyms: JWH 200 2'-naphthyl isomer;[1-(2-morpholin-4-ylethyl)indol-3-yl]-naphthalen-2-ylmethanone
• CAS NO: 133438-66-1
• Molecular Formula: C25H24N2O2
• Molecular Weight: 384.47026
• Mol File: 133438-66-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: JWH 200 2'-naphthyl isomer(CAS DataBase Reference)
• NIST Chemistry Reference: JWH 200 2'-naphthyl isomer(133438-66-1)
• EPA Substance Registry System: JWH 200 2'-naphthyl isomer(133438-66-1)

Safety Data

• Hazardous Substances Data: 133438-66-1(Hazardous Substances Data)

Usage

General Description

JWH 200 2'-naphthyl isomer is a synthetic cannabinoid compound that acts on the cannabinoid receptors in the brain, producing effects similar to those of THC, the active compound in cannabis. It is a potent agonist at both the CB1 and CB2 receptors, leading to its psychoactive effects. JWH 200 2'-naphthyl isomer has a similar chemical structure to other synthetic cannabinoids, making it a popular choice for recreational drug use. However, its use can be associated with a range of adverse effects, including anxiety, paranoia, and increased heart rate. The compound is often found in illegal drugs marketed as "fake weed" or "herbal incense" and is associated with a high risk of abuse and dependence.

Upstream product

• 72395-48-3 1-<2-(4-morpholinyl)ethyl>-1H-indole 
• 2243-83-6 2-naphthaloyl chloride 
• 93-09-4 naphthalene-2-carboxylate 

Relevant articles and documents

Aminoalkylindoles: Structure - Activity Relationships of Novel Cannabinoid Mimetics

Aminoalkylindoles (AAIs) are a novel series of cannabinoid receptor ligands.In this report we disclose the structural features of AAIs which are important for binding to this receptor as measured by inhibition of binding of 3H>Win 55212-2 (5).Functional activity in the mouse vas deferens is also noted and used to distinguish agonists from potential antagonists.The key structural features for potent cannabinoid activity in this series are a bicyclic (naphthyl) substituent at the 3-position, a small (H) substituent at the 2-position, and an aminoethyl (morpholinoethyl) substituent at the 1-position.A 6-bromo analog, Win 54461 (31), has been identified as a potential cannabinoid receptor antagonist.Modeling experiments were done to develop a pharmacophore and also to compare AAI structures with those of classical cannabinoids.The fact that the cannabinoid AAIs arose out of work on a series of cyclooxygenase inhibitors makes sense now that an endogenous cannabinoid ligand has been identified which is a derivative of arachidonic acid.Because of their unique structures and physical properties, AAIs provide useful tools to study the structure and function of the cannabinoid receptor(s).