133438-72-9

Basic information

• Product Name: JWH 200 5-hydroxyindole metabolite
• Synonyms: JWH 200 5-hydroxyindole metabolite;[5-hydroxy-1-(2-morpholin-4-ylethyl)indol-3-yl]-naphthalen-1-ylmethanone
• CAS NO: 133438-72-9
• Molecular Formula: C25H24N2O3
• Molecular Weight: 400.46966
• Mol File: 133438-72-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: JWH 200 5-hydroxyindole metabolite(CAS DataBase Reference)
• NIST Chemistry Reference: JWH 200 5-hydroxyindole metabolite(133438-72-9)
• EPA Substance Registry System: JWH 200 5-hydroxyindole metabolite(133438-72-9)

Safety Data

• Hazardous Substances Data: 133438-72-9(Hazardous Substances Data)

Upstream product

• 86-53-3 1-Cyanonaphthalene 
• 622-40-2 2-(morpholin-4-yl)ethanol 
• 46230-78-8 2-(morpholin-1-yl)ethyl methanesulfonate 

Relevant articles and documents

Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment

Cannabinoid type 2 (CB2) receptor continues to emerge as a promising drug target for many diseases and conditions. New tools for studying CB2 receptor are required to further inform how this receptor functions in healthy and diseased states. The alkyl indole scaffold is a well-recognised ligand for cannabinoid receptors, and in this study the indole C5-7 positions were explored for linker and fluorophore attachment. A new high affinity, CB2 receptor selective inverse agonist was identified (16b) along with a general trend of C5-substituted indoles acting as agonists versus C7-substituted indoles acting as inverse agonists. The indole C7 position was found to be the most tolerant to linker extension and resulted in a high affinity inverse agonist with a medium length linker (19). Although a high affinity fluorescent ligand for CB2 receptor was not identified in this study, the indole C7 position shows great promise for fluorophore or probe attachment.